49 results

Suitability of new drugs registered in Brazil from 2003 to 2013 for pediatric age groups

Jaqueline Cristina da Silveira Xavier e Castro ORCID logo , Stephanie Ferreira Botelho ORCID logo , Taisa Roberta Lopes Machado ORCID logo , Maria Auxiliadora Parreiras Martins ORCID logo , Liliana Batista Vieira ORCID logo , Adriano Max Moreira Reis ORCID logo

DOI: 10.31744/einstein_journal/2018AO4354

ABSTRACT Objective To analyze suitability of new drugs registered in Brazil from 2003 to 2013 for pediatric age groups. Methods A descriptive study of drugs with pediatric indication included in a retrospective cohort of new drugs registered in Brazil. The evaluation of drug suitability for the pediatric age group was performed using the following criteria: suitability of dosage form and capacity to deliver the recommended dose. The drugs were considered adequate for the pediatric age groups when they met both […]

Latent tuberculosis infection and tuberculosis in children and adolescents

Cassia Satsuki Ishikawa ORCID logo , Olivia Mari Matsuo ORCID logo , Flavio Sarno ORCID logo

DOI: 10.1590/S1679-45082018AO4090

ABSTRACT Objective: To describe the characteristics of patients diagnosed with tuberculosis and latent tuberculosis infection. Methods: A retrospective study, between 2012 and 2015, with data from patients of Programa Einstein na Comunidade de Paraisópolis. To evaluate possible factors associated with patient’s sex and diagnoses of tuberculosis and latent tuberculosis infection, χ2 or Fisher’s exact tests were used for qualitative variables, and Mann-Whitney test for quantitative or ordinal qualitative variables. Results: A total of 77 patients were evaluated. Age ranged from […]

Circumcision: postoperative complications that required reoperation

Carolina Talini ORCID logo , Letícia Alves Antunes ORCID logo , Bruna Cecília Neves de Carvalho ORCID logo , Karin Lucilda Schultz ORCID logo , Maria Helena Camargo Peralta Del Valle ORCID logo , Ayrton Alves Aranha Junior ORCID logo , [...]

DOI: 10.1590/S1679-45082018AO4241

ABSTRACT Objective To evaluate post-operative complications of circumcision requiring surgical reintervention. Methods Retrospective analysis of medical records of patients submitted to circumcision from May 1st, 2015 to May 31st, 2016. Results A total of 2,441 circumcisions were performed; in that, 1,940 using Plastibell and 501 by the classic technique. Complications requiring surgical reintervention were found in 3.27% of patients. When separated by surgical technique, 3.4% of circumcisions using Plastibell device required reoperation, as compared to 3% of conventional technique (p=0.79). […]

Clinical and immunohistochemical study of melanotic neuroectodermal tumor of infancy in the maxilla

Hellen Bandeira de Pontes Santos, Aníbal Henrique Barbosa de Luna, Pedro Everton Marques Goes, Alexander Tadeu Sverzut, Cassiano Francisco Weege Nonaka, Pollianna Muniz Alves

DOI: 10.1590/S1679-45082018RC4025

ABSTRACT Melanotic neuroectodermal tumor of infancy is a rare and fast-growing neoplasm. In this study, we describe the case of a 6-month-old female patient, who presented swelling in the anterior maxilla. Tomographic reconstruction showed an unilocular hypodense and expansive area associated with the upper right central primary incisor. The presumptive diagnoses were dentigerous cyst, adenomatoid odontogenic tumor, melanotic neuroectodermal tumor of infancy and rhabdomyosarcoma, and an incisional biopsy was performed. Microscopically, the lesion revealed a biphasic cell population, consisting of […]

Association between hypovitaminosis D and frequency of pulmonary exacerbations in children and adolescents with cystic fibrosis

Renata Ongaratto, Katiana Murieli da Rosa, Juliana Cristina Eloi, Matias Epifanio, Paulo Marostica, Leonardo Araújo Pinto

DOI: 10.1590/S1679-45082018AO4143

Abstract Objective We evaluated the association between vitamin D levels and nutritional status, pulmonary function and pulmonary exacerbations in children and adolescents with cystic fibrosis. Methods 25-hydroxyvitamin D (25(OH)D) levels of 37 children and adolescents were retrospectively evaluated. Pulmonary function, body mass index, height for age, and pulmonary exacerbations episodes were associated with vitamin D levels divided into two groups: sufficient (≥30ng/mL) and hypovitaminosis (

Specificities of presentation of Crohn’s disease in childhood

Bruna Karoline Pinheiro França Protásio, Camila Maria Pinheiro Machado Martins Barbosa, Clarice Blaj Neufeld, Leandro Dimasi Buck, Lygia de Souza Lima Laund, Mauro Sergio Toporovski, [...]

DOI: 10.1590/S1679-45082017RC4070

ABSTRACT The incidence of inflammatory bowel disease in the pediatric population has increased in the last years. The most common form of inflammatory bowel disease is Crohn’s disease and, according to its form and age of presentation, it is possible to predict the evolution of the disease.

Spontaneous breathing test in the prediction of extubation failure in the pediatric population

Milena Siciliano Nascimento, Celso Moura Rebello, Luciana Assis Pires Andrade Vale, Érica Santos, Cristiane do Prado

DOI: 10.1590/S1679-45082017AO3913

ABSTRACT Objective To assess whether the spontaneous breathing test can predict the extubation failure in pediatric population. Methods A prospective and observational study that evaluated data of inpatients at the Pediatric Intensive Care Unit between May 2011 and August 2013, receiving mechanical ventilation for at least 24 hours followed by extubation. The patients were classified in two groups: Test Group, with patients extubated after spontaneous breathing test, and Control Group, with patients extubated without spontaneous breathing test. Results A total […]

Comparison of enterovirus detection in cerebrospinal fluid with Bacterial Meningitis Score in children

Frederico Ribeiro Pires, Andréia Christine Bonotto Farias Franco, Alfredo Elias Gilio, Eduardo Juan Troster

DOI: 10.1590/S1679-45082017AO3880

ABSTRACT Objective To measure the role of enterovirus detection in cerebrospinal fluid compared with the Bacterial Meningitis Score in children with meningitis. Methods A retrospective cohort based on analysis of medical records of pediatric patients diagnosed as meningitis, seen at a private and tertiary hospital in São Paulo, Brazil, between 2011 and 2014. Excluded were patients with critical illness, purpura, ventricular shunt or recent neurosurgery, immunosuppression, concomitant bacterial infection requiring parenteral antibiotic therapy, and those who received antibiotics 72 hours […]

Hospitalization costs of severe bacterial pneumonia in children: comparative analysis considering different costing methods

Sheila Elke Araujo Nunes, Ruth Minamisava, Maria Aparecida da Silva Vieira, Alexander Itria, Vicente Porfirio Pessoa Junior, Ana Lúcia Sampaio Sgambatti de Andrade, [...]

DOI: 10.1590/S1679-45082017GS3855

ABSTRACT Objective To determine and compare hospitalization costs of bacterial community-acquired pneumonia cases via different costing methods under the Brazilian Public Unified Health System perspective. Methods Cost-of-illness study based on primary data collected from a sample of 59 children aged between 28 days and 35 months and hospitalized due to bacterial pneumonia. Direct medical and non-medical costs were considered and three costing methods employed: micro-costing based on medical record review, micro-costing based on therapeutic guidelines and gross-costing based on the […]

Prevalence of inter-hemispheric asymetry in children and adolescents with interdisciplinary diagnosis of non-verbal learning disorder

Alessandra Bernardes Caturani Wajnsztejn, Bianca Bianco, Caio Parente Barbosa

DOI: 10.1590/s1679-45082016ao3722

ABSTRACTObjectiveTo describe clinical and epidemiological features of children and adolescents with interdisciplinary diagnosis of non-verbal learning disorder and to investigate the prevalence of inter-hemispheric asymmetry in this population group.Methods Cross-sectional study including children and adolescents referred for interdisciplinary assessment with learning difficulty complaints, who were given an interdisciplinary diagnosis of non-verbal learning disorder. The following variables were included in the analysis: sex-related prevalence, educational system, initial presumptive diagnoses and respective prevalence, overall non-verbal learning disorder prevalence, prevalence according to school […]

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