All publications of “Tatiane Morgana da Silva”

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Standardization of an experimental model suitable for studies on the effect of exercise on arthritis

Raquel Pinheiro Gomes, Elisangela Bressan, Tatiane Morgana da Silva, Monique da Silva Gevaerd, Carlos Rogério Tonussi, Susana Cristina Domenech

DOI: 10.1590/S1679-45082013000100014

Objective:To standardize an experimental model of chronic monoarthritis induced by complete Freund’s adjuvant appropriate for the analysis of the effect of walking on nociception and on joint edema.METHODS:The following factors were evaluated as to monoarthritis induction: route and site of administration, number and interval of inoculations, Mycobacterium species, and animal gender. Wistar male and female rats (200 to 250g) received two injections of complete Freund’s adjuvant containing Mycobacterium tuberculosis (1.0mg/mL; 50µL) or Mycobacterium butyricum (0.5mg/mL; 50µL) intra-articularly in the tibiotarsal […]