All publications of “Morton Aaron Scheinberg”

6 results

Partnership for productive development of biosimilar products: perspectives of access to biological products in the Brazilian market

Morton Aaron Scheinberg ORCID logo , Paulo Antonio Oldani Felix ORCID logo , Igor Age Kos ORCID logo , Maurício De Angelo Andrade ORCID logo , Valderilio Feijó Azevedo ORCID logo

DOI: 10.1590/S1679-45082018RW4175

ABSTRACT The manufacturing process for biological products is complex, expensive and critical to the final product, with an impact on their efficacy and safety. They have been increasingly used to treat several diseases, and account for approximately 50% of the yearly budget for the Brazilian public health system. As the patents of biological products expire, several biosimilars are developed. However, there are concerns regarding their efficacy and safety; therefore, the regulatory agencies establish rules to approve and monitor these products. […]

Bone health in cerebral palsy and introduction of a novel therapy

Morton Aaron Scheinberg, Ricardo Prado Golmia, Adriana Maluf Elias Sallum, Maria Guadalupe Barbosa Pippa, Aline Pinheiros dos Santos Cortada, Telma Gomes da Silva

DOI: 10.1590/S1679-45082015AO3321

ABSTRACTObjective To assess the bone health status of children with cerebral palsy and the therapeutic effect of denosumab in a subgroup of children with cerebral palsy and decreased bone mass.Methods Children with cerebral palsy were evaluated according to their motor disability score (classification system gross motor functions III to V), bone density and bone turnover markers. Dual X-ray energy absorption was used to measure the lumbar spine, and total body, except the head. Thereafter a group of children with cerebral […]

Comparison of thromboprophylaxis patterns in arthroplasty in public and private hospitals

Aline Pinheiro dos Santos Cortada, Telma Gomes da Silva, André Campos da Silva, Ricardo Prado Golmia, Renata Leborato Guerra, Maíra Libertad Soligo Takemoto, [...]

DOI: 10.1590/S1679-45082015GS3057

ObjectiveTo compare therapy for prophylaxis of venous thromboembolism and costs related to hospitalization of patients undergoing total knee and hip replacement within the context of the Brazilian health system.MethodsA retrospective study of patients undergoing arthroplasty in 2010 in a public hospital and two private hospitals in the state of São Paulo, conducted by means of medical record review. Costs were estimated based on the use of health care resources during hospitalization. A descriptive analysis was performed using frequency and mean […]

Use of rituximab as a treatment for systemic lupus erythematosus: retrospective review

Roberta Ismael Lacerda Machado, Morton Aaron Scheinberg, Maria Yvone Carlos Formiga de Queiroz, Danielle Christinne Soares Egypto de Brito, Maria Fernanda Brandao de Resende Guimarães, Raquel Altoé Giovelli, [...]

DOI: 10.1590/S1679-45082014AO2706

Objective:To report the experience in three Brazilian institutions with the use of rituximab in patients with different clinical forms of lupus erythematosus systemic in activity.Methods: The study consisted of a sample of 17 patients with LES, who were already being treated, but that at some stage of the disease showed refractory symptoms. The patients were subdivided into groups according to the clinical manifestation, and the responses for the use of rituximab were rated as complete, partial or no response. Data […]

Retention rates of infliximab and tocilizumab during a 3-year period in a Brazilian hospital

Ricardo Prado Golmia, Morton Aaron Scheinberg

DOI: 10.1590/S1679-45082013000400015

Objective:To compare the efficacy and the period of use of tocilizumab and infliximab during treatment of rheumatoid arthritis patients.METHODS:The period of use of two biologics with different mechanisms of action were compared in treatment of rheumatoid arthritis patients. RES: ULTS: Both medications showed efficacy, but the period of use with no loss of efficacy was longer in patients receiving tocilizumab when compared to infliximab.CONCLUSION:Tocilizumab maintains a period of use significantly longer as compared with infliximab in patients with rheumatoid arthritis […]

Diagnosis of growing pains in a Brazilian pediatric population: a prospective investigation

Luciana Pereira Almeida de Piano, Ricardo Prado Golmia, Andrea Pimentel Fonseca Golmia, Adriana Maluf Elias Sallum, Lucia Akemi Nukumizu, Damião Guedes Castro, [...]

DOI: 10.1590/S1679-45082010AO1692

ABSTRACT Objective: To establish the clinical aspects of growing pains and to determine, through differential diagnosis, how many patients who referred themselves to a specialized clinic were found to have growing pains. Methods: This study prospectively examined the presence of growing pains in a self-reported population of children and adolescents with signs and symptoms (lower limb pains) of unexplained etiology. Results: A total of 345 children and adolescents were evaluated; 174 (50.4%) were males and 171 (49.6%) were females. Three […]