All publications of “Milton de Arruda Martins”

2 results

Sensitization by subcutaneous route is superior to intraperitoneal route in induction of asthma by house dust mite in a murine mode

Marcelo Vivolo Aun, Beatriz Mangueira Saraiva-Romanholo, Francine Maria de Almeida, Thayse Regina Brüggemann, Jorge Kalil, Milton de Arruda Martins, [...]

DOI: 10.1590/S1679-45082015AO3389

ABSTRACTObjective To develop a new experimental model of chronic allergic pulmonary disease induced by house dust mite, with marked production of specific immunoglobulin E (IgE), eosinophilic inflammatory infiltrate in the airways and remodeling, comparing two different routes of sensitization.Methods The protocol lasted 30 days. BALB/c mice were divided into six groups and were sensitized subcutaneously or intraperitoneally with saline (negative control), Dermatophagoides pteronyssinus (Der p) 50 or 500mcg in three injections. Subsequently they underwent intranasal challenge with Der p or […]

Potentially inappropriate medication prescribed to elderly outpatients at a general medicine unit

Christine Grützmann Faustino, Milton de Arruda Martins, Wilson Jacob Filho

DOI: 10.1590/S1679-45082011AO1844

ABSTRACT Objective: To establish the prevalence of potentially inappropriate medications prescribed for elderly patients, to identify the most commonly involved drugs, and to investigate whether age, sex and number of medications were related with the prescription of these drugs. Methods: Prescriptions for 1,800 elderly patients (≥ 60 years) were gathered from a database. These prescriptions were written by general physicians at a tertiary level university hospital in the city of Sao Paulo, Brazil, from February to May 2008. Only one […]