All publications of “Jose Mauro Kutner”

8 results

The rare holley antibody associated with a severe hemolytic transfusion reaction: the importance of this antibody identification to find a compatible blood unit

Leandro Dinalli Santos ORCID logo , Carolina Bonet Bub ORCID logo , Maria Giselda Aravechia ORCID logo , Eduardo Peres Bastos ORCID logo , Jose Mauro Kutner ORCID logo , Lilian Castilho ORCID logo

DOI: 10.31744/einstein_journal/2020RC4582

ABSTRACT The correct identification of erythrocyte antibodies is fundamental for the searching for compatible blood and haemolytic transfusion reactions prevention. Antibodies against antigens of high prevalence are difficult to identify because of the rarity of their occurrence and unavailability of negative red cells for confirmation. We report a case of 46-years-old woman, diagnosed with hemoglobinopathy, and who had symptomatic fall in hemoglobin levels (5.3g/dL) after blood transfusion suggestive of transfusion reaction. The patient’s blood type was O RhD-positive. Irregular antibody […]

Allele and haplotype frequencies of human platelet and leukocyte antigens in platelet donors

Valeria de Freitas Dutra ORCID logo , Carolina Bonet Bub ORCID logo , Thiago Henrique Costa ORCID logo , Leandro Dinalli Santos ORCID logo , Eduardo Peres Bastos ORCID logo , Maria Giselda Aravechia ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4477

ABSTRACT Objective To described the allele and haplotype frequencies of human leukocyte antigen genes at the -A, -B loci and human platelet antigen genes for human platelet antigen systems 1 to 9, 11 and 15 in blood. Methods We included 867 healthy unrelated volunteer donors who donated platelets between January 2011 and December 2014. Microarray genotyping was performed using a BeadChip microarray. Medium resolution typing of the human leukocyte antigen at loci A and B was carried out using sequence-specific […]

Successful management of neonatal alloimmune thrombocytopenia in the second pregnancy: a case report

Fabiana Mendes Conti, Sergio Hibner, Thiago Henrique Costa, Marcia Regina Dezan, Maria Giselda Aravechia, Ricardo Antonio D’Almeida Pereira, [...]

DOI: 10.1590/S1679-45082014RC2729

Neonatal alloimmune thrombocytopenia is a serious disease, in which the mother produces antibodies against fetal platelet antigens inherited from the father; it is still an underdiagnosed disease. This disease is considered the platelet counterpart of the RhD hemolytic disease of the fetus and newborn, yet in neonatal alloimmune thrombocytopenia the first child is affected with fetal and/or neonatal thrombocytopenia. There is a significant risk of intracranial hemorrhage and severe neurological impairment, with a tendency for earlier and more severe thrombocytopenia […]

Prevalence of erythrocyte alloimmunization in polytransfused patients

Roberto de Oliveira Cruz, Mariza Aparecida Mota, Fabiana Mendes Conti, Ricardo Antônio d'Almeida Pereira, Jose Mauro Kutner, Maria Giselda Aravechia, [...]

DOI: 10.1590/S1679-45082011AO1777

ABSTRACT Objective: To determine the incidence and the rate of red blood cell alloimmunization in polytransfused patients. Methods: A polytransfused patient was defined as having received at least 6 units of red cell concentrates during a 3-month period. The records of all patients (n = 12,904) who had received red blood cell units were examined retrospectively by searching the computer database at Hospital Israelita Albert Einstein in São Paulo, Brazil, over a 6-year period, between 2003 and 2009. Results: During […]

Allogeneic hematopoietic stem cell transplantation in children with primary immunodeficiencies: Hospital Israelita Albert Einstein experience

Juliana Folloni Fernandes, Fabio Rodrigues Kerbauy, Andreza Alice Feitosa Ribeiro, Jose Mauro Kutner, Luis Fernando Aranha Camargo, Adalberto Stape, [...]

DOI: 10.1590/S1679-45082011AO2007

ABSTRACT Objective: To report the experience of a tertiary care hospital with allogeneic hematopoietic stem cell transplantation in children with primary immunodeficiencies. Methods: Seven pediatric patients with primary immunodeficiencies (severe combined immunodeficiency: n = 2; combined immunodeficiency: n = 1; chronic granulomatous disease: n = 1; hyper-IgM syndrome: n = 2; and IPEX syndrome: n = 1) who underwent eight hematopoietic stem cell transplants in a single center, from 2007 to 2010, were studied. Results: Two patients received transplants from […]

Factors affecting autologous peripheral blood hematopoietic stem cell collections by large-volume leukapheresis:a single center experience

Araci Massami Sakashita, Andrea Tiemi Kondo, Andreza Alice Feitosa Ribeiro, Andrea Neri Folchini Cipolletta, Monica Vilela Colesanti, Nelson Hamerschlak, [...]

DOI: 10.1590/S1679-45082011AO1932

ABSTRACT Objective: To evaluate factors affecting peripheral blood hematopoietic stem cell yield in patients undergoing large-volume leukapheresis for autologous peripheral blood stem cell collection. Methods: Data from 304 consecutive autologous peripheral blood stem cell donors mobilized with hematopoietic growth factor (usually G-CSF), associated or not with chemotherapy, at Hospital Israelita Albert Einstein between February 1999 and June 2010 were retrospectively analyzed. The objective was to obtain at least 2 × 106 CD34+ cells/kg of body weight. Pre-mobilization factors analyzed included […]

Use of gemtuzumab ozogamycin combined with conventional chemotherapy in patients with acute myeloid leukemia

Guilherme Fleury Perini, Fabio Pires de Souza Santos, Iracema Esteves, Claudia Mac-Donald Bley do Nascimento, Morgani Rodrigues, Reijane Alves de Assis, [...]

DOI: 10.1590/S1679-45082011AO1987

ABSTRACT Objective: To analyze the outcome of patients treated with gemtuzumab ozogamycin combined with conventional therapy treated at Hospital Israelita Albert Einstein. Methods: 14 patients who had high risk features (secondary leukemia, unfavorable cytogenetics, and refractory disease) were treated with gemtuzumab ozogamycin combined with conventional therapy and their outcome was analysed by reviewing their medical records. Results: Overall response rate was 58%, with 43% achieving complete response, with a median follow-up of 11 months, event-free survival was 3 months. Eleven […]

Autologous stem-cell transplantation for multiple myeloma: a Brazilian institution experience in 15 years of follow-up

Juliana Todaro, Ana Rita de Araújo Burgos Manhani, José Mauro Kutner, Andreza Alice Feitosa Ribeiro, Morgani Rodrigues, Fabio Rodrigues Kerbauy, [...]

DOI: 10.1590/S1679-45082011AO1845

ABSTRACT Objective: To determine the 5-year post-transplant survival of patients with multiple myeloma. Methods: A retrospective study in patients diagnosed with multiple myeloma submitted to autologous bone marrow transplantation at a Brazilian institution, during the period of 1993 to 2007. Results: Seventy-three patients were evaluated with a median age of 55 years. Survival in 5 years was 75% (2.4 to 60 months). Statistical analysis demonstrated statistical significance for the applied grade of response prior to treatment with autologous bone marrow […]