All publications of “Janyerson Dannys Pereira da Silva”

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Pharmacological characterization of the calcium influx pathways involved in nitric oxide production by endothelial cells

Janyerson Dannys Pereira da Silva ORCID logo , Gustavo Ballejo ORCID logo

DOI: 10.31744/einstein_journal/2019AO4600

ABSTRACT Objective: To characterize the calcium influx pathways implicated in the sustained elevation of endothelial intracellular calcium concentration, required for the synthesis and release of relaxing factors. Methods: We evaluated the effect of the newly synthesized pyrazole derivatives, described as selective inhibitors for ORAI (BTP2/Pyr2 and Pyr6) and TRPC3 (Pyr3 and Pyr10) channels, upon endothelium- and extracellular calcium-dependent relaxations stimulated by acetylcholine and thapsigargin, in pre-constricted rat thoracic aortic rings. Results: Acetylcholine and thapsigargin responses were completely reverted by Pyr2 […]