All publications of “Jacqueline Holanda de Sousa”

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Evaluation of the concentration of malondialdehyde and nitrite in patients with sickle cell anemia treated or not with hydroxyurea

Darcielle Bruna Dias Elias, Rivelilson Mendes de Freitas, Romélia Pinheiro Gonçalves, Hemerson Yuri Ferreira Magalhães, Jacqueline Holanda de Sousa, Silvia Maria Meira Magalhães

DOI: 10.1590/S1679-45082010AO1731

ABSTRACT Objective: To determine the serum levels of malondialdehyde and nitrite in patients with sickle cell anemia treated or not with hydroxyurea in outpatient’s setting. Methods: Of the 65 patients with sickle cell anemia selected for the study, 51 were not treated with hydroxyurea (Group 1), 14 made chronic use of hydroxyurea (Group 2) and 20 individuals had no hemoglobinopathies (Control Group). Results: The Control Group had a lower and more homogeneous concentration of malondialdehyde levels as compared to the […]