All publications of “Helio Rodrigues da Silva”

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Therapeutic evaluation of magnetic hyperthermia using Fe3O4-aminosilane-coated iron oxide nanoparticles in glioblastoma animal model

Gabriel Nery de Albuquerque Rego ORCID logo , Javier Bustamante Mamani ORCID logo , Taylla Klei Felix Souza ORCID logo , Mariana Penteado Nucci ORCID logo , Helio Rodrigues da Silva ORCID logo , Lionel Fernel Gamarra ORCID logo

DOI: 10.31744/einstein_journal/2019AO4786

ABSTRACT Objective: To evaluate the potential of magnetic hyperthermia using aminosilane-coated superparamagnetic iron oxide nanoparticles in glioblastoma tumor model. Methods: The aminosilane-coated superparamagnetic iron oxide nanoparticles were analyzed as to their stability in aqueous medium and their heating potential through specific absorption rate, when submitted to magnetic hyperthermia with different frequencies and intensities of alternating magnetic field. In magnetic hyperthermia in vitro assays, the C6 cells cultured and transduced with luciferase were analyzed by bioluminescence in the absence/presence of alternating […]