All publications of “Francisco Romero Cabral”

3 results

Preclinical molecular imaging: development of instrumentation for translational research with small laboratory animals

Jorge Mejia, Ana Claudia Camargo Miranda, Ana Claudia Ranucci Durante, Larissa Rolim de Oliveira, Marycel Rosa Felisa Figols de Barboza, Katerin Taboada Rosell, [...]

DOI: 10.1590/S1679-45082016AO3696

ABSTRACTObjective:To present the result of upgrading a clinical gamma-camera to be used to obtain in vivo tomographic images of small animal organs, and its application to register cardiac, renal and neurological images.Methods:An updated version of the miniSPECT upgrading device was built, which is composed of mechanical, electronic and software subsystems. The device was attached to a Discovery VH (General Electric Healthcare) gamma-camera, which was retired from the clinical service and installed at the Centro de Imagem Pré-Clínica of the Hospital […]

SPEM: a state-of-the-art instrument for high resolution molecular imaging of small animal organs

Marilia Alves dos Reis, Jorge Mejia, Ilza Rosa Batista, Marycel Rosa Felisa Figols de Barboza, Solange Amorim Nogueira, Jairo Wagner, [...]

DOI: 10.1590/S1679-45082012000200015

Objective:To describe the Single Photon Emission Microscope (SPEM), a state-of-the-art instrument for small animal SPECT imaging, and characterize its performance presenting typical images of different animal organs.METHODS:SPEM consists of two independent imaging devices based on high resolution scintillators, high sensitivity and resolution Electron-Multiplying CCDs and multi-pinhole collimators. During image acquisition, the mouse is placed in a rotational vertical holder between the imaging devices. Subsequently, an appropriate software tool based on the Maximum Likelihood algorithm iteratively produces the volumetric image. Radiopharmaceuticals […]

Tumor growth analysis by magnetic resonance imaging of the C6 glioblastoma model with prospects for the assessment of magnetohyperthermia therapy

André César da Silva, Francisco Romero Cabral, Javier Bustamante Mamani, Jackeline Moraes Malheiros, Roberson Saraiva Polli, Alberto Tannus, [...]

DOI: 10.1590/S1679-45082012000100004

Objective:The objective was to establish a pattern of tumor growth of the C6 model of glioblastoma multiform in Wistar rats via magnetic resonance imaging (MRI) for the subsequent verification of tumor volume reduction due to magnetic hyperthermia therapy.METHODS:Young male Wistar rats weighing between 250 and 300 g were used for the C6 model. After the rates were anesthetized (55 mg/kg ketamine and 11 mg/kg xylazine), C6 lineage tumorigenic cells suspended in culture medium (10(5) cells in 10 µl) were stereotaxically […]