All publications of “Amanda Soares Alves”

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Immunosenescence: participation of T lymphocytes and myeloid-derived suppressor cells in aging-related immune response changes

Amanda Soares Alves ORCID logo , Valquiria Bueno ORCID logo

DOI: 10.31744/einstein_journal/2019RB4733

ABSTRACT Healthy aging is partly related to appropriate function of the immune system. As already reported, some changes in this system are observed, including reduced number and repertoire of T cells due to thymic involution, accumulation of memory T cells by chronic infections, homeostatic proliferation compensating for the number of naïve T cells, decreased proliferation of T cells against a stimulus, telomere shortening, replicative senescence of the T cells, and inflammaging, besides the accumulation of myeloid-derived suppressor cells. The purpose […]