All publications of “William Tadeu Festuccia”

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Regulation of adiposity by mTORC1

Juliana Magdalon, William Tadeu Festuccia

DOI: 10.1590/S1679-45082017RB4106

ABSTRACT Obesity is characterized by an excessive increase in the adipose tissue mass, and is associated with higher incidence of several chronic metabolic diseases, such as type 2 diabetes. Therefore, its increasing prevalence is a public health concern, and it is important to better understand its etiology to develop new therapeutic strategies. Evidence accumulated over the years indicates that obesity is associated with a marked activation in adipose tissue of the mechanistic target of rapamycin complex 1 (mTORC1), a signaling […]