All publications of “Thiago Henrique Costa”

2 results

Allele and haplotype frequencies of human platelet and leukocyte antigens in platelet donors

Valeria de Freitas Dutra ORCID logo , Carolina Bonet Bub ORCID logo , Thiago Henrique Costa ORCID logo , Leandro Dinalli Santos ORCID logo , Eduardo Peres Bastos ORCID logo , Maria Giselda Aravechia ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4477

ABSTRACT Objective To described the allele and haplotype frequencies of human leukocyte antigen genes at the -A, -B loci and human platelet antigen genes for human platelet antigen systems 1 to 9, 11 and 15 in blood. Methods We included 867 healthy unrelated volunteer donors who donated platelets between January 2011 and December 2014. Microarray genotyping was performed using a BeadChip microarray. Medium resolution typing of the human leukocyte antigen at loci A and B was carried out using sequence-specific […]

Successful management of neonatal alloimmune thrombocytopenia in the second pregnancy: a case report

Fabiana Mendes Conti, Sergio Hibner, Thiago Henrique Costa, Marcia Regina Dezan, Maria Giselda Aravechia, Ricardo Antonio D’Almeida Pereira, [...]

DOI: 10.1590/S1679-45082014RC2729

Neonatal alloimmune thrombocytopenia is a serious disease, in which the mother produces antibodies against fetal platelet antigens inherited from the father; it is still an underdiagnosed disease. This disease is considered the platelet counterpart of the RhD hemolytic disease of the fetus and newborn, yet in neonatal alloimmune thrombocytopenia the first child is affected with fetal and/or neonatal thrombocytopenia. There is a significant risk of intracranial hemorrhage and severe neurological impairment, with a tendency for earlier and more severe thrombocytopenia […]