All publications of “Monica Spadafora-Ferreira”

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Contrasting roles of donor and recipient TGFB1 and IFNG gene polymorphic variants in chronic kidney transplant rejection

Verônica Porto Carreiro de Vasconcellos Coelho, Rafael Ioschpe, Cristina Caldas, Monica Spadafora-Ferreira, João Americo Fonseca, Maria Regina Alves Cardoso, [...]

DOI: 10.1590/S1679-45082011AO1852

ABSTRACT Objective: To assess the long-term impact (minimum of 3 years follow-up) of polymorphisms in cytokine genes in donor:recipient pairs on the results of the transplant. Methods: We compared genetic cytokine polymorphisms and the primary factors of risk for the development of chronic rejection in paired groups of renal transplant patients with and without chronic allograft nephropathy [CAN]. Results: Multivariate analysis indicated that the presence of the high-production TT genotype (codon 10) of the transforming growth factor beta-1 (TGFB1) was […]