All publications of “Karina Scaramuzzi”

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Nanostructured SBA-15 silica as an adjuvant in immunizations with hepatitis B vaccine

Karina Scaramuzzi, Denise Cristina André Oliveira, Luciana Vieira Carvalho, Denise Vilarinho Tambourgi, Elisabeth Christina Nunes Tenório, Marisa Rizzi, [...]

DOI: 10.1590/s1679-45082011ao2162

ABSTRACTObjective:To evaluate the applicability of SBA-15 silica as an adjuvant in immunizations with purified particles of the viral protein HBsAg, the main component of hepatitis B vaccine, Butang®, produced by Instituto Butantan.Methods:BALB/c mice orally or subcutaneously received 0.5 μg of HBsAg adsorbed/encapsulated to SBA-15 or adsorbed to Al(OH)3. To assess the secondary immune response, a subcutaneous booster was administered 30 days after the first immunization. Individual serum and fecal samples of each group were periodically collected for specific antibody titration […]