All publications of “Alberto Tannús”

3 results

Manganese-enhanced magnetic resonance imaging in the acute phase of the pilocarpine-induced model of epilepsy

Jackeline Moraes Malheiros, Beatriz Monteiro Longo, Alberto Tannús, Luciene Covolan

DOI: 10.1590/S1679-45082012000200023

Magnetic resonance images are useful in the study of experimental models of temporal lobe epilepsy. The manganese-enhanced MRI (MEMRI) technique is of interest since it combines the effects caused by manganese on the increased contrast in activated cell populations, when competing with calcium in synaptic transmission. Thus, the purpose of this study was to investigate the temporal evolution of the contrast related to manganese in the acute phase of temporal lobe epilepsy induced by systemic pilocarpine and compare it to […]

In vivo magnetic resonance imaging tracking of C6 glioma cells labeled with superparamagnetic iron oxide nanoparticles

Javier Bustamante Mamani, Jackeline Moraes Malheiros, Ellison Fernando Cardoso, Alberto Tannús, Paulo Henrique Silveira, Lionel Fernel Gamarra

DOI: 10.1590/S1679-45082012000200009

Objective:The aim of the current study was to monitor the migration of superparamagnetic iron oxide nanoparticle (SPION)-labeled C6 cells, which were used to induce glioblastoma tumor growth in an animal model, over time using magnetic resonance imaging (MRI), with the goal of aiding in tumor prognosis and therapy.METHODS:Two groups of male Wistar rats were used for the tumor induction model. In the first group (n=3), the tumors were induced via the injection of SPION-labeled C6 cells. In the second group […]

Tumor growth analysis by magnetic resonance imaging of the C6 glioblastoma model with prospects for the assessment of magnetohyperthermia therapy

André César da Silva, Francisco Romero Cabral, Javier Bustamante Mamani, Jackeline Moraes Malheiros, Roberson Saraiva Polli, Alberto Tannus, [...]

DOI: 10.1590/S1679-45082012000100004

Objective:The objective was to establish a pattern of tumor growth of the C6 model of glioblastoma multiform in Wistar rats via magnetic resonance imaging (MRI) for the subsequent verification of tumor volume reduction due to magnetic hyperthermia therapy.METHODS:Young male Wistar rats weighing between 250 and 300 g were used for the C6 model. After the rates were anesthetized (55 mg/kg ketamine and 11 mg/kg xylazine), C6 lineage tumorigenic cells suspended in culture medium (10(5) cells in 10 µl) were stereotaxically […]